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Miro Bio

Antibody Development: Senior/Principal Scientist

– Oxford, Oxfordshire
Employment Type Full Time
Minimum Experience Experienced
Compensation DOE

Company Description

MiroBio is a recently launched biologics company with a mission to treat a range of autoimmune and inflammatory disorders. The company is founded by leading immunologists at the University of Oxford who have spent over 15yrs focussed on understanding the mechanisms which underlie T-cell signalling. The technology is based on an IP portfolio of novel antibodies with the ability to activate inhibitory co-receptors on the surface of immune cells, with a deep mechanistic understanding, MiroBio is able to optimise these antibodies to create immune-modulatory therapies which have shown remarkable efficacy in preclinical models of disease. MiroBio is now building out the team and the platform looking for strong antibody-development expertise to take the lead compounds to clinical proof-of-concept.

MiroBio is a well-funded spin-out from the Oxford University. The company is based in Oxford, retaining close links to the world-class immunology expertise and clinical trial experience within the University.

 Role Description

Reporting to:            Robert Boyd – Snr Director, Preclinical

 Location:                   Initially at the BioEscalator – Oxford

                                       Long-term facilities will be accessible from central Oxford

Salary:                        Dependent on Experience

The preclinical development of antibody therapeutics requires a deep understanding of antibody pharmacology and developability. We are looking for a Senior or Principal scientist with validated experience in preclinical antibody development to support antibody pharmacodynamic/kinetic and stability studies.

This is a key role to propel our novel therapeutic antibodies from discovery to the clinic. A focus on detail and quality are essential for this role. Strong communication skills and adaptability are also requirements for this position.

 Core Responsibilities

  • Lead the antibody pharmacology aspects of therapeutic programs, provide in vivo physiology and pharmacology
  • Develop pharmacological strategies and implement experimental approaches for therapeutic antibody programs
  • Investigate the pharmacokinetics, pharmacodynamics and bio distribution of antibody therapeutics 
  • Analyse antibody structure and stability for developability 
  • Work closely with external contractors and consultants to outsource pre-clinical studies
  • Technology transfer assays to external CMC, safety and bio-analytics contractors 
  • Work with the team to plan and implement translational research including pharmacodynamic markers of target engagement, biomarkers predictive of or correlating with clinical efficacy and disease biology 
  • Preparation of study reports for regulatory filings

 Role qualification and requirements:

  • PhD in Biochemistry/Pharmacology and immunology background
  • Experience in preclinical antibody development in an industrial setting
  • Good understanding of preclinical PK/PD/efficacy relationships and their translation to the clinic
  • Strong experimental understanding of the assays and methodologies used to measure antibody structure and stability 
  • Proven in vivo pharmacology skills with animal models, and experience overseeing the design, execution and interpretation of studies  
  • Validated experience of engaging and managing external in vivo efforts with contract research organizations 
  • Working knowledge of preclinical and clinical biomarker discovery and development
  • Experience in writing preclinical reports and presenting research data
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  • Location
    Oxford, Oxfordshire
  • Employment Type
    Full Time
  • Minimum Experience
    Experienced
  • Compensation
    DOE
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